Sunday, July 22, 2012

Novel anti-malarial drug target identified

Friday, July 20, 2012

An international team of scientists, led by researchers from the Department of Pediatrics at the University of California, San Diego School of Medicine, have identified the first reported inhibitors of a key enzyme involved in survival of the parasite responsible for malaria. Their findings, which may provide the basis for anti-malarial drug development, are currently published in the online version of the Journal of Medicinal Chemistry.

Tropical malaria is responsible for more than 1.2 million deaths annually. Severe forms of the disease are mainly caused by the parasite Plasmodium falciparum, transmitted to humans by female Anopheles mosquitoes. Malaria eradication has not been possible due to the lack of vaccines and the parasite's ability to develop resistance to most drugs.

The researchers conducted high-throughput screening of nearly 350,000 compounds in the National Institutes of Health's Molecular Libraries Small Molecule Repository (MLSMR) to identify compounds that inhibit an enzyme which plays an important role in parasite development: Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PD) is essential for proliferating and propagating P. falciparum.

"The enzyme G6PD catalyzes an initial step in a process that protects the malaria parasite from oxidative stress in red blood cells, creating an environment in which the parasite survives," said senior author Lars Bode, PhD, assistant professor in the UCSD Department of Pediatrics, Division of Neonatology and the Division of Gastroenterology, Hepatology and Nutrition. People with a natural deficiency in this enzyme are protected from malaria and its deadly symptoms, an observation that triggered the reported research.

The parasitic form of the enzyme (PfG6PD) is what contributes the majority of G6PD activity in infected red blood cells. Because the parasite lives in the blood of a malaria-infected person, the scientists aimed at identifying compounds that inhibit the parasitic form but not the human form of the enzyme. "We didn't want to interfere with the human form of the enzyme and risk potential side effects," Bode explained.

Scientific testing had previously been limited by a lack of recombinant PfG6PD. Team members in the lab of Katja Becker, PhD, at the Interdisciplinary Research Center at Justus-Liebig-University in Giessen, Germany produced the first complete and functional recombinant PfG6PD, and researchers led by Anthony Pinkerton, PhD, at Sanford-Burnham Medical Research Institute used it to identify the lead compound resulting from their efforts, ML276.

ML276 represents the first reported selective PfG6PD inhibitor, which stops the growth of malaria parasites in cultured red blood cells ? even those parasites that developed resistance to currently available drugs. "ML276 is a very promising basis for future drug design of new anti-malarial therapeutics," said Bode.

###

University of California - San Diego: http://www.ucsd.edu

Thanks to University of California - San Diego for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/121903/Novel_anti_malarial_drug_target_identified_

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$450000 :: 430 9th ST, Lake Oswego OR, 97034 ? Lake Oswego ...

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3 beds, 1 full, 1 part baths
Home size: 2,356 sq ft
Lot Size: 6,098 sq ft
Property Type: DETACHD
MLS Number: 12674750

Beautiful gardens surround this charming cottage in the heart of First Addition. Master on main, hdwds thru much of main level, updates include living room fireplace, family room skylights and certified wood stove that exudes warmth and character. 840 SF of unfinished basement adds tremendous potential! Perfect location near library/shops/restaurants.

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The content relating to real estate for sale on this web site comes in part from the IDX program of the RMLS? of Portland, Oregon. All real estate listings are marked with the RMLS? logo, and detailed information about these properties includes the names of the listing brokers. Listing content is ? 2009 RMLS?, Portland, Oregon.


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Sunday, July 15, 2012

Peaceful Table: Vegan Milk Crumbs

Christina Tosi of Momofuku Milk Bar created something called Milk Crumbs, which?she adds?to?some of?her famous, non-vegan dessert recipes.? Her Milk Crumbs are made with nonfat cow- milk?powder.?Now, with Vegan Milk Crumbs, we?can make Tosi's?basic recipes without killing?anyone.? You see, when we drink cows' milk,?we flood our bodies with the natural pregnancy hormones of?suffering, innocent?beings.? And we?also personally create a system where cows are forcibly impregnated their entire lives so they will lactate to "give" us milk.? And all the male baby cows born from these pregnancies are chained for their short lives, and then literally dragged to slaughter because they cannot walk.? And they are never allowed one drop of their own mothers' milk.? So, if we're drinking cow's milk and eating cheese, we might?as well be eating veal.? And all this is aside from the foreign, heart-stopping cholesterol we take in.? We don't drink horse milk, and we are the only species who will drink the milk of another animal.? And did you know that drinking cow milk actually thins bones?? It's true and you can find many?studies that show it.? When we have the Meat and Dairy councils funding the American Food Pyramid and financing medical schools, it's no wonder we have been duped for generations.
********
Vegan Milk Crumbs

Makes enough for?a batch of cookies.

INGREDIENTS
1/4 Cup plus 1 Tablespoon of Better Than Milk Soy Powder
???? ?(with 2 Tablespoons plus 1.5 teaspoons set aside)
2 Tablespoons all-purpose flour
1 Tablespoon cornstarch
1.5 teaspoons sugar
1/8 teaspoon fine sea salt
1.5 Tablespoons Earth Balance?Buttery Sticks, melted
1/4 Cup vegan white chocolate chips, melted

DIRECTIONS
Preheat oven to 225 degrees Fahrenheit.
Line a baking sheet with parchment paper and set aside.
In a medium bowl, whisk together 2 Tablespoons plus 1.5 teaspoons milk powder, flour cornstarch, sugar and salt.
Stir in melted vegan butter until well combined.
Spread mixture on prepared baking sheet and transfer to oven.
Bake until dried and crumbly, about 25-30 minutes or so.
Remove milk crumble from oven and let cool completely.
Chop up coarsely.
First, transfer Milk Crumble to?medium mixing bowl and fold in remaining Better Than Milk?Powder and toss gently.
Then, add melted white chocolate and fold in gently.
Use immediately, or transfer to an airtight container and keep refrigerated until ready to use.
If necessary, chop cold Milk Crumbs further.

Notes:? I get?my white chocolate chips from The Vegan Store, but you can also buy them from Vegan Essentials, etc.? ?Christina Tosi uses these?Milk Crumbs in various recipes, including her Blueberry and Cream Cookies.?

Source: http://peacefultable.blogspot.com/2012/07/vegan-milk-crumbs.html

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Saturday, July 14, 2012

Michael Ardan: What Happened When I Hit On a Hot Guy... And Not on Grindr

I have never had a Grindr account. I have never answered a Craigslist personal ad (though I have found myself perusing the Missed Connections, just in case Anderson Cooper saw me on the N train and was too shy to say something. Don't be shy, Andy.). I have never logged onto Manhunt, or Adam4Adam, or any other such site. Please don't get me wrong, I don't judge anyone for their choices concerning their own personal relationships, phsical or otherwise, but I can't even get into the idea of Internet dating, let alone Internet sexing. To me, there is something oddly cold about the impersonality of the ever-increasing use of technology in dating/hookup culture. And perhaps that's the point; there is certainly an entire subculture of people -- gay and straight, men and women -- who are attracted to (or at least turned on by) the increased ease of casual sexual encounters. To me it just seems lazy. We can now quite literally use our iPhones and Blackberries to order in everything from dinner to drinks to hookups. Surely there is still something to be said for traditional methods.

I was thinking about this one recent evening after a particularly messy breakup, as I found myself drinking alone on a Tuesday night at the Cubby Hole, a cool little neighborhood bar in the West Village known for its super-strong $2 margaritas. After having a few drinks and chatting up a friendly lesbian named Carol who was sitting next to me at the bar, I glanced up just in time to lock eyes with a highly attractive guy ordering a drink a few feet away. I was probably staring for just a little too long, but he just smiled, took his drink -- a rum and coke -- and walked back toward his group of friends.

Now, if life were a romantic comedy, this would have been the part normally known as the "meet-cute." You know, the scene where Reese Witherspoon/Kate Hudson/Jennifer Aniston (or, if you're feeling nostalgic, Meg Ryan/Julia Roberts/Diane Keaton) has the slightly-awkward-in- an-endearing-way chance meeting with [insert hunky actor here], and everyone watching at home just knows they're going to end up together in the end. Unfortunately, most of our lives are not Hollywood rom-coms, and instead we find ourselves thrown into the dating world without a script or an audience rooting for us from their sofas.

The way I see it, we have a couple of options. We can either sit passively and wait for the right person to approach us, eventually realize it's not going to happen, and duck into a corner to sign onto to Grindr (not the greatest strategy), or we can take charge and be willing to "put ourselves out there," so to speak. It's a scary thing, definitely, to open yourself up to the possibility of being shot down, especially in a crowded bar. But as with everything in life, anything worth having is worth working for. It just so happened that on this particular night I was newly single and had built up a respectable buzz, so naturally I was feeling a little bold. I politely excused myself to my new friend Carol and made my way over to Mr. Rum and Coke.

At this point I should probably mention that meeting people in New York isn't exactly hard; they're all over the place. Meeting normal people is another story. Maybe it's all the rushing around; all those people constantly moving can make anyone a little neurotic. Or maybe it's the absolute ridiculousness of having 8 million people all cramped together. Whatever the reason, one thing is for sure: Whether you're gay or straight, meeting nice, dateable people in New York is no walk in the proverbial park (Central or Gramercy. Rimshot.). So sometimes you just have to be willing to take a chance, and I definitely had a good feeling about this guy. And as I approached, he noticed me coming and shot me another adorable smile.

"Rum and coke, right?" I asked, pointing at his drink. "How's the rum here?" (Sidenote: When you put yourself out there, sometimes you will say completely stupid things like, "How's the rum here?" Chalk it up to a learning experience and move on.)

"Not bad. I saw you at the bar. Are you here with friends?" he asked.

"Yeah," I said, motioning my glass towards Carol, who was now deep in conversation with some girl who had taken my seat.

And so it began. Fifteen minutes later we had both ordered a fresh drink and were deep in conversation. I'd learned that his name was James and that he, like me, had grown up in the South and liked puppies. Things in common!

"So what's your story?" James asked during a brief lull in the conversation. "Are you single?" This guy was moving fast. And I kind of liked it. Not to get all Sex and the City, but that's the thing about putting yourself out there. Sometimes it's totally life-in-the-fast-lane.

"Yeah," I said, leaving it at that. I briefly considered telling him the whole story of my breakup and my evening drinking cheap margaritas by myself, but fortunately I wasn't quite drunk enough to lay all that crazy out on the table.

As we were finishing our drinks, James' phone started buzzing. "It's my friends," he said, checking the screen. "They're outside waiting for me. Listen, I have to run. But if you get bored here, you should call me and come meet up." And then he reached into his pocket and pulled out a business card. I kid you not.

"OK," I said, taking his card. His card. Classy.

And with that, he flashed yet another cute smile and walked off.

I stood there for a moment, a little unsure of what exactly had just happened, but feeling pretty good about myself nonetheless. Had an attractive, seemingly normal guy just given me his number? I looked down at the card. Ten perfectly printed digits, followed by a name: James. No last name, just James. And then, under that, typed in bold font, two more words: Male Escort. And his rates.

Now, if life were a John Hughes film (and if I was Molly Ringwald circa 1986), this would be the part where I covered my face with my fashionable, homemade handbag and hurried to the bathroom before anyone noticed my face flushed with embarrassment. But I didn't. Despite the outcome, I felt pretty OK.

In this crazy world where impersonal tools like Grindr and (God forbid) Craigslist all too often replace real, human connections, I had swallowed my pride and hit on a hot stranger, which had given me the confidence to do it all over again next time, and I hadn't even so much as glanced at my Blackberry. That, to me, is a victory in itself. This is how meeting people is supposed to go. We stumble along the way, we end up with a few crazy stories, and eventually we get back up and do it all over again until the odds finally tip in our favor. It's all about the journey. Think about that the next time you find yourself tempted to give in to the ease and accessibility of handing over your sex life to an app.

Just be aware that "putting yourself out there" also means opening yourself up to the possibility of rejection and/or rentboys.

?

Follow Michael Ardan on Twitter: www.twitter.com/michaelardan

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Source: http://www.huffingtonpost.com/michael-ardan/what-happened-when-i-hit-on-a-hot-guy_b_1672393.html

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Gustav Klimt: Why some say 'The Kiss' is better than the 'Mona Lisa'

'The Kiss' by Gustav Klimt?? the painting shown in Saturday's Google Doodle ? may not be as recognizable as the 'Mona Lisa.' But the golden painting may be better.

By Chris Gaylord / July 14, 2012

Gustav Klimt painted "The Kiss" from 1907 to 1908. But this is the Google Doodle honoring Klimt and his work. (Check out an image of the original below.)

Google

Enlarge

When Google decided to honor painter?Gustav Klimt with a Google Doodle, choosing the right image probably didn't take too long.

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The company mostly likely wanted to show something from his "Golden Period," a time when Klimt lavished his work with gold leaf. The team couldn't pick one of his many nude images (many in the early 1900s described his work as "pornography"). Plus, the Google Doodle crew probably wanted to display his best work, like, say, a painting that some believe to be better than the "Mona Lisa."

So, the search engine replaced its regular logo with an homage to Klimt's "The Kiss."?

The painting shows a couple embracing. While we see their faces, most of their bodies hide behind gilded ropes. Gold douses the background, too, creating a glimmering fog around the pair ? as if, in this moment, they were the only things left in this world.?

What about "The Kiss" makes it so?special??The golden painting is certainly less?recognizable?than the "Mona Lisa," a painting that is a top contender for the world's most famous piece of art. Critics praise the "Mona Lisa" for its?technique,?atmosphere, composition, and?mysterious smile.

That said, the Mona Lisa might be better experienced in a book than in real life. The actual painting is rather small ? and appears smaller still considering the crowd that always surrounds it. If you want to examine the brushstrokes and?appreciate?the artistry, you'd best look for a print.

"Unlike the Mona Lisa, which disappoints when you confront it...?'The Kiss' by Gustav Klimt surpasses expectations," writes?journalist Adrian Brijbassi. "For one thing, it?s not nearly as celebrated a painting, so public fascination isn?t high to begin with. More importantly, though, it does what a great piece of art is supposed to do: Hold your gaze, make you admire its aesthetic qualities while trying to discern what?s beyond its superficial aspects."

Canadian artist?Charles Moffat backs up this first impression. He says that "The Kiss" is "widely considered to be the greatest painting ever, better than even the Mona Lisa."?

Klimt never kept a journal and rarely wrote about his own work. Because of this, people need to?interpret?the work for themselves. Alfred Weidinger, curator of the Belvedere Palace Museum in Vienna, Austria, where "The Kiss" resides, imagines that the scene shows two lovers sitting beside a lake. The early morning light shines on the water, creating the golden gleam that dominates the painting.

The ropes signify the love between the couple. It's hard to tell where one person stops and the other?begins. In this moment, they are one.

Just as the "Mona Lisa" has an enigmatic smile, "The Kiss" has its own curious expression. It's hard to tell if the woman welcomes the embrace. She almost seems asleep, perhaps dreaming of a perfect love and a golden wardrobe.

"The Kiss" also mixes together a very modern style with aspects of older art, such as myths (the floral crown atop the man),?religious?artwork (particularly Christian icons), and the more?contemporary?Arts and Crafts movement.?

Not everyone agrees on the importance of this painting, nor of Klimt's legacy. He is undeniably popular ? in 2006, Klimt's portrait "Adele Bloch-Bauer I" sold for $135 million, the highest price ever reported on a painting. (Last year, a piece by Paul Cezanne broke the record with a $250 million bid.) But popularity doesn't mean that you influence other artists. ?

"Klimt, of course, is an important artist ? he's a very?popular?artist ? but in terms of the history of art, he's a very unimportant artist," said writer Frank Whitford in a BBC special about "The Kiss," according to a transcript.?"Although he sums up so much in his work, about the society in which he found himself ? in art historical terms his effect was negligible. So he's an artist really in a cul-de-sac."

What do you think about "The Kiss"? How do you?interpret?the scene? Let us know in the comments below.

For more on how technology intersects daily life, follow Chris on?Twitter @venturenaut.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/TPhjXfixblk/Gustav-Klimt-Why-some-say-The-Kiss-is-better-than-the-Mona-Lisa

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Video: How Brees' deal impacts others QBs

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Source: http://nbcsports.msnbc.com/id/21134540/vp/48180680#48180680

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Friday, July 13, 2012

Panel calls for annual PTSD screening

The Institute of Medicine recommended Friday that soldiers returning from Iraq and Afghanistan undergo annual screening for post-traumatic stress disorder and that federal agencies conduct more research to determine how well the various treatments for PTSD are working.

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Of the 2.6 million service members deployed to Iraq and Afghanistan, it's estimated that 13 percent to 20 percent have symptoms of PTSD.

Federal agencies have increasingly dedicated more resources to screen and treat soldiers, but considerable gaps remain, according to the Institute of Medicine, an independent group of experts that advises the federal government on medical issues. Its recommendations often make their way into laws drafted by Congress and policies implemented by federal agencies.

Barely more than half of those diagnosed with PTSD actually get treatment, often because many soldiers worry it could jeopardize their careers. Also, when soldiers do get care, they're not tracked to determine which treatments are successful in the long-term.

Related: Mental health group says combat PTSD deserved Purple Heart
Related: Veteran fights VA to keep PTSD diagnosis

The Department of Defense provides medical care to active members of the military and the Department of Veterans Affairs cares for those who no longer serve. Sandro Galea, the chairman of the IOM panel, said both departments offer many programs for PTSD.

"But treatment isn't reaching everyone who needs it, and the departments aren't tracking which treatments are being used or evaluating how well they work in the long term," said Galea, a professor and chair of the epidemiology department at Columbia University. "In addition, DOD has no information on the effectiveness of its programs to prevent PTSD."

The report concludes only the first phase of the Institute of Medicine study. The panel is hoping to release a second report in 2014 that will provide more specifics about the number of service members and vets who have PTSD and the outcomes and costs of their treatments.

Nick Colgin, who served for 15 months in Afghanistan as a combat medic, suffered a traumatic brain injury after a rocket-propelled grenade slammed into his Humvee. While he showed symptoms of PTSD upon his return to civilian life, he waited to get treatment until just last month.

"I just didn't want anyone to know I had that issue. I didn't want to know myself," said Colgin, 27, now living in New York City and working with the advocacy group Iraq and Afghanistan Veterans of America.

Jason Hansman, the group's membership director, said the stigma of seeking treatment is even more prevalent among those on active-duty.

"A lot of people believe their career will end if they seek treatment," Hansman said.

In a recent speech to mental health provides, Defense Secretary Leon Panetta said commanding officers must make it understood that seeking help for the stresses of war should be seen as a sign of strength rather than as a sign of weakness.

PTSD is triggered by a specific traumatic event, such as being in combat or witnessing death. The symptoms of the illness include a numbing of emotions, difficulty concentrating and exaggerated startled responses to events.

The institute recommended therapies supported by robust evidence, such as working with patients to change their thinking and emotional responses to stress. But the committee's analysis of other innovative treatments, including yoga, acupuncture and animal-assisted therapy, is hampered by a lack of evidence on their effectiveness.

Galea said that the two departments have been under quite a bit of pressure to get programs up and running to deal with the growing number of vets with PTSD.

"There hasn't been as much premium placed on tracking than there has been on implementing treatment," Galea said.

The panel praised the two departments for issuing joint guidelines for managing PTSD, but it's unknown whether their providers adhere to the guidelines. The panel said that primary care doctors within the VA screen Iraq and Afghanistan veterans annually for symptoms of PTSD, and it recommends that the Defense Department do the same.

The panel said it is hopeful that the departments will make more use of therapy through videoconferences that will allow patients in remote locations to get care.

The panel also called for more research to shed light on the brain's defense mechanisms for stress, identify factors that can influence the timing and severity of symptoms and identify signs that could help lead to earlier diagnosis and more precise drug treatments.

The report said that the VA treated more than 438,000 veterans for PTSD in 2010, showing evidence of the widespread scope of the problem. Similar numbers are not available for the Defense Department.

Cynthia O. Smith, a DOD spokeswoman, said the department has already taken steps to address some of the issues raised in the report.

"The department recognizes the need for continued improvements," Smith said.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.msnbc.msn.com/id/48178032/ns/us_news/

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